FORMULATION AND EVALUATION OF SUMATRIPTAN SUCCINATE AND NAPROXEN SODIUM GASTRORETENTIVE (FLOATING) BILAYERED TABLETS

Abstract

The main aim of the present work was to formulate and evaluate sumatriptan succinate and naproxen sodium gastro retentive(floating) bilayered tablets. Floating bilayer tablets were formulated using direct compression method, it consist of two layers i.e IR layer containing Naproxen and floating CR layer containing sumatriptan. IR2 layer containing 2% concentration of Cross Povidone was found to be optimum and released 99.23% of naproxen in 45min. The optimized floating CR8 layer containing HPMC K 100M in 46% concentration showed 81.21% of drug release at the end of 12h. Among all formulations, IR2 & CR8 provided slow release of sumatriptan over 12h and rapid release of naproxen within 45 min, hence it is considered as an optimum bilayered formulation of sumatriptan and naproxen. The optimised formulation was fitted in the Kinetic models and it follows Korsmeyer-Peppas kinetics and the release mechanism was Case II non- fickian diffusion from these tablets.