Affiliation:
1. Department of Pharmacology, Mandya Institute of Medical Sciences, Mandya, Karnataka – 571401
Abstract
At the time of cataract surgery, one of the challenges a surgeon encounters is intraoperative miosis. This might increase the chances of intraoperative and postoperative complications. Thus, maintainence of adequate pupillary dilatation is necessary during cataract surgery. Aim of the study was to compare the effectiveness of prophylactic administration of topical bromfenac (0.09 % w/V) and topical flurbiprofen (0.03 % w/V) in maintaining mydriasis during the cataract surgery. A total of 100 patients were randomly divided into two groups of 50 each. Group 1 received topical bromfenac (0.09 %) and Group 2 received topical flurbiprofen (0.03 %). The mean percentage loss of mydriasis from the baseline was lesser in bromfenac group compared to flurbiprofen group (p < 0.001). Topical bromfenac was found to be more effective in maintaining mydriasis during the cataract surgery when compared to the topical flurbiprofen.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
Reference19 articles.
1. 1. Singh S, Pardhan S, Kulothungan V, Swaminathan G, Ravichandran J S, Ganesan S, Sharma T and Raman R.: The prevalence and risk factors for cataract in rural and urban India, Indian J. Ophthalmol, 2019, 67(4) 477-483.
2. 2. World Health Organization, Geneva, Blindness and vision impairment prevention, Available at https://www.who.int/blindness/causes/priority/en/index1.html
3. 3. Bansal G, Gupta S, Kumar S and Kansal S.: Comparison of The Effect of Topical Bromfenac With Nepafenac in Maintaining Mydriasis During Cataract Surgery, Delhi J. Opthalmol, 2015, 26(2) 97-100.
4. 4. Gupta S, Bansal G and Kumar S.: Role of Topical NSAIDs in Maintaining Mydriasis during Cataract Surgery with Special Emphasis on Nepafenac, Bromfenac, Opthalmol. Clin. Res, 2019, 2(2) 84-86.
5. 5. Giménez-Bastida JA, Shibata T, Uchida K and Schneider C.: Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes, FASEB J, 2017, 31(5) 1867-1878.