Affiliation:
1. Dept. of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, BSK II stage, Bengaluru-560070
Abstract
Flemingia strobilifera R.Br. (Fabaceae), is a perennial plant traditionally used as an indigenous medicine for its pharmacological characteristics. The goal of our experimentation was to study the chloroform extract of F. strobilifera roots for its anti-inflammatory potential through anti-inflammatory models like carrageenan - elicited rat hind paw edema , cotton pellet - elicited granuloma formation, and carrageenan - elicited leucocyte to justify ethno-medicinal use of the plant. Indomethacin, a reference drug, was used to compare anti-inflammatory potential. The extract, administered respectively with a lower dose of 30 mg and 60 mg per kg body weight as higher dose, three hour post treatment, produced a significant reduction (p < 0.01) in the edema of paw and substantial decrease in implanted cotton pellets dry weight. We conclude that the chloroform extract of roots of F. strobilifera possess osedependent, anti-inflammatory activity.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
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