Author:
Bajaj Himani, ,Singh Vinod,Singh Ranjit,Kumar Tirath, , ,
Abstract
The objective of the present study was to prepare a topical film-forming gel of aceclofenac for the treatment of rheumatic diseases, using a safe and effective drug delivery approach. Aceclofenac film-forming gels were prepared using hydroxypropyl methyl cellulose and chitosan polymeric blend in varying concentrations, polyethylene glycol 400 (PEG 400) as a plasticizer, Tween 80 as a permeation enhancer and ethanol as solvent. The prepared film-forming gels were evaluated and the influence of the concentration and ratio of polymeric blends, plasticizer, and ethanol used were investigated. All the prepared film-forming gels showed satisfactory properties regarding consistency, spreadability and thickness. Variation in the concentration of polymers, ethanol and PEG 400 showed a variable effect on drying time from film-forming gels. Film-forming gels of aceclofenac were successfully developed and may provide a promising effective formulation that may improve patient compliance.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
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