Author:
Gautam Seema,Chandra Sulekh,Singh Jugmendra,Manav Navneet,Paliwal Vinod K,Kumar Amit,
Abstract
Structure and biological application based analysis has been carried out for Schiff’s base ligand containing nitrogen and sulphur donor atoms and also for a series of its coordination compounds. Ligand benzil-bis(5-amino-1,3,4-thiadiazole-2-thiol) (L) has been prepared and structural features of ligand investigated by elemental analyses, IR, 1 H-NMR, mass spectra and molecular modeling studies. The chemical reaction of the prepared ligand with metal ions afforded mononuclear coordination compounds of Mn(II) and Co(II) metal ions. The characterization of the coordination compounds is being based on the techniques i.e. elemental analysis, infra-red, UV-visible as well as melting point, molar conductivity and magnetic moment measurement. A computational study has been done to understand the miscellaneous coordination modes of ligand to metal ions. Characterization result shows that coordination compounds exhibit a six coordinated geometrical arrangement i.e. octahedral geometry. The biological inhibition zone (antifungal and antibacterial activities) of synthesized compounds, i.e. ligand and its coordination compounds, has been monitored using well diffusion technique
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
Reference36 articles.
1. Kushwaha N., Kushwaha S.K.S., Rai A.K.; Biological activities of thiadiazole derivatives: a review, Int. J. ChemTech Res., 2012, 4(2) 517-531.
2. Avaji P.G., Patil S.A., Badami P.S.; Synthesis, spectral, thermal, solid state, electrical conductivity and biological studies of Co(II), Ni(II) and Cu(II) complexes with 3-substituted-4-amino(indole-3-aldehydo)-5-mercapto-1,2,4-triazole schiff bases, J. Coord. Chem., 2008, 61(12) 1884-1896.
3. Koutentis P.A.; The preparation and characterization of 5-substituted-4-chloro-1,2,3-dithiazolium salts and their conversion into 4-substituted-3-chloro-1,2,5-thiadiazoles, Molecules, 2005, 10(2) 10346-359.
4. Ugras H.I., Basaran I., Kilic T., Cakir U.; Synthesis, complexation and antifungal, antibacterial activity studies of a new macrocyclic Schiff bases, J. Heterocycl. Chem., 2006, 43(6) 1679-1684.
5. Salimon J., Salih N., Ibraheem H., Yousif E.; Synthesis of 2-N-salicylidene-5-(substituted)-1,3,4-thiadiazole as potential antimicrobial agents, Asian J. Chem., 2010, 22(7) 5289-5296.