RAPID GREEN SYNTHESIS OF GOLD AND SILVER NANOPARTICLES USING ETHANOL EXTRACT OF KEDROSTIS FOETIDISSIMA (JACQ.) COGN. AND ITS ANTICANCER EFFICACY AGAINST A549 HUMAN LUNG CANCER CELL LINES

Abstract

This study is mainly focused on the synthesis of gold and silver nanoparticles using Kedrostis foetidissima (Jacq.) Cogn, a traditional medicinal plant, their characteristics and their efficacy on Human Lung cancer cell lines (A-549). Gold and silver nanoparticles were synthesised using ethanol extract of K. foetidissima by solar irradiation method. The formation of gold nanoparticles (AuNPs) and silver nanoparticles (AgNps) were authenticated by UV-Visible, FT-IR, XRD SEM, and TEM analysis. The solar irradiation method yielded beautiful floral shaped AuNPs and spherical shaped AgNPs of the size 8.38 nm and 33.20 nm, respectively. The cytotoxicity effect of these biogenic nanoparticles against A-549 cell lines was monitored through MTT assay. The results have revealed that AgNps shows significant cytotoxicity (IC50-62.16 µg/mL) towards A-549 than AuNPs (IC50- 106.27 µg/mL). The shape dependency of the nanoparticles is also clear from the study