PREPARATION AND EVALUATION OF IBUPROFEN LIQUID FILL FORMULATIONS FOR SOFT GELS-Reference-Cited by-同舟云学术

PREPARATION AND EVALUATION OF IBUPROFEN LIQUID FILL FORMULATIONS FOR SOFT GELS

Published:2017-12-28 Issue:12 Volume:54 Page:65-68
ISSN:0019-462X
Container-title:INDIAN DRUGS
language:en
Short-container-title:IND. DRU.

Author:

Sudhir M.,Manjusha M.,Manjula R.R.,Jyothi N.,Lakshmi Prasanthi N.,

Abstract

The present investigation was undertaken with an objective to prepare and evaluate liquid fill formulations of non-steroidal anti-inflammatory drug, ibuprofen (IBU), in order to improve its dissolution properties and thereby its bioavailability. Liquid fill formulations were prepared by employing different co-solvents and surfactants like polyethylene glycol 400 (PEG 400), propylene glycol (PG) and polyvinylpyrrolidone (PVP K-30). The liquid fills were characterized by assay, rheology, clarity, in vitro dissolution studies and FTIR. More than 90% of the drug was released within 5 min from PVP K30 based formulations. Formulations containing PVP K 30 gave better dissolution properties when compared to formulations without PVP K 30, and complete drug dissolution was observed within 5min. Compatibility studies of IBU PEG 400, PG and PVP by IR method indicated that the excipients are compatible.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

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