Author:
Palariya Lalita, ,Bawari Sweta,Sah Archana N.
Abstract
The objective of the present study is to develop and evaluate microsphere and tablet in capsule system for the treatment of rheumatoid arthritis as a dual pulse release system. The capsule system contains enteric coated cap filled with microspheres (sustained release) that lock the impermeable capsule body (coated with ethyl cellulose). The capsule body consists of diclofenac sodium loaded core tablet in the bottom (immediate release), which is sealed with swellable hydrogel plug tablet. Formulations selected for capsule system were MP1 due to least particle size (90.44±0.20 μm) and maximum cumulative release (91.49±0.20 %), T3 for least disintegration time (4±0.040 min) and maximum cumulative release (85.50±0.09 %) and HP2 for maintenance of lag phase that was 6 h and in vitro study was Performed. This formulation included two pulses in one system for reduction of dose frequency and better treatment of night pain and morning stiffness in rheumatoid arthritis patients.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
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