VISIBLE SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF MODAFINIL IN PHARMACEUTICAL FORMULATION

Abstract

Two simple, sensitive, and fast visible spectrophotometric techniques for quantifying modafinil in marketed dosage form have been proposed. The method A was focussed on the complexation involving charge transfer with picric acid to give pale yellow colored chromogen which shows absorption maxima at 450 nm. In the concentration range of 5-40 μg mL-1, Beer’s law is obeyed with a correlation value of 0.999. The method B depends on the oxidative coupling process with MBTH in the presence of FeCl3 in acidic pH to give green colour chromogen which shows absorption maxima at 657 nm. In the concentration range of 10-50 μg mL-1, Beer’s law was obeyed with a correlation value of 0.999. The developed methodologies have been statistically verified for use in quality control laboratories for pharmaceuticals