Author:
Nishal Suchitra, ,Phaugat Parmita,Tushir Renu,Dhall Manish
Abstract
Polymeric microspheres enclosing an extremely porous surface are termed as microsponges. Microsponges are drug loaded microporous beads having 10-25 micron diameter. These may augment stability, ease side effects and amend drug release. Microsponge systems have capability to capture ample drug substances and are then formulated into various products like gel, cream, liquid or powder. Several research studies corroborated that microsponge entities possess non-irritant, non-mutant, non-allergic and non-toxicity features. Suitable analytical techniques for characterization of microsponges can be illustrated for suitable characteristic properties such as thickness, particle size and its distribution, surface and pore properties. Many problems such as repulsive odor, greasiness and skin exasperation are resolved by MDDS (microsponge drug delivery system). MDDS generates prolonged release and site specific action. In this review article, a concise outline of MDDS covering the principle, methods of formulation and characterization have been discussed. Microsponge delivery system (MDS) is primarily utilized for topical and oral formulations but it is also being explored for cosmetic formulations.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
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