SYNTHESIS, COMPUTATIONAL AND IN VITRO ANTI-DIABETIC STUDIES OF NOVEL THIAZOLIDIN-4-ONES DERIVATIVES

Abstract

A new series of thiazolidin-4-ones (T1-10) were synthesized by the reaction of Schiff’s bases(Ta-j) and thioglycolic acid in dioxane medium in the presence of anhydrous zinc chloride as a catalyst. All the newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral data and studied for in vitro antidiabetic activity. Most of the synthesized derivatives showed promising antidiabetic activity. This work indicates that the presence of the -OH group attached to the ring may be responsible for the activity. The new compounds were subjected to in silico analysis.