WOUND HEALING, ANTIMICROBIAL AND ANTIOXIDANT POTENTIALS OF CEDRUS DEODARA LOUD. AND PINUS ROXBURGHII SARG.

Abstract

The aim of this study was to investigate wound healing, antimicrobial and antioxidant activities of Cedrus deodara and Pinus roxburghii. The chloroform extract of C. deodara was found to possess significant wound healing potential, as evident from the rate of wound contraction, epithelization and hydroxyproline expression. The chloroform extract of C. deodara also exhibited very good antimicrobial activity and a marked dose-dependent reducing power and total antioxidant activity. Furthermore, five sesquiterpenes, namely, atlantone, himaphenolone, atlantolone, deodardione, and (E)-(2S, 3S, 6R)-atlantone-2, 3-diol, were also identified from this extract. A marked dose-dependent reducing power and strong total antioxidant capacity were found in favor of himaphenolone and (E)-(2S, 3S, 6R)-atlantone-2, 3-diol that explain the possible means of activity. The chloroform extract of C. deodara showed the wound healing, antimicrobial and antioxidant activities primarily due to the presence of sesquiterpenes. This study showed a scientific rationale for the traditional use of C. deodara and P. roxburghii