STRUCTURE ELUCIDATION AND BIOLOGICAL INVESTIGATION OF INORGANIC COORDINATION COMPOUNDS DERIVED FROM CITRACONIC ANHYDRIDE AND 5-AMINO-1,3,4-THIADIAZOLE-2-THIOL ORGANIC MOIETY

Abstract

The increasing clinical and microbiological resistance of fungi and bacteria enhanced discovery of several fungicidal and bactericidal drugs. Now it is necessary to discover novel drugs which can kill microorganisms but following the condition that these drugs should not be harmful for the host. In this research work we synthesized some novel transition metal complexes (inorganic coordination compounds) of ligand citraconicanhydride-bis(5-amino-1,3,4-thiadiazole-2-thiol) which act as antifungal and antibacterial agents. Ligand is synthesized by the condensation reaction of citraconicanhydride and 5-amino-1,3,4-thiadiazole-2-thiol, in ethanolic medium. Structure of ligand and complexes have been characterized by melting point, elemental analysis, 1H-NMR, mass, electronic spectra, molar conductance, magnetic moment, infra-red, uv-visible, electron paramagnetic resonance and molecular modeling study. Biological investigation of all synthesized compounds has been carried out by using pathogenic fungi C.albicans, C.krusei, C.parapsilosis and C.tropicalis and bacteria E. coli and S. aureus at different concentrations of compounds. Results of biological investigation by using well diffusion method show that metal complexes were more potent than free ligand. Results from biological investigation studies have also shown that complexation of metals with ligand serves to improve their activity.