CHEMO PREVENTIVE EFFECT OF PIPERINE IN N-NITROSODIETHYLAMINEINDUCED AND PHENOBARBITAL PROMOTED EXPERIMENTAL RAT HEPATOCELLULAR CARCINOMA

Author:

Yadala P. C,Viswanath Swamy A H M,

Abstract

Every year, almost 5, 00,000 new patients are diagnosed with hepatocellular carcinoma (HCC), primary malignancy of the liver that is associated with poor prognosis. In recent years, development of efficient anti-cancer agents from natural sources has become a major focus of researchers. The present study was designed to investigate the preventive and therapeutic effects of piperine against DEN induced HCC in male wistar rats. Twenty four rats were divided into four groups (n=6). Group I serves as Control, Group II were induced with HCC by DEN (200mg/kg b.wt) followed by phenobarbital (0.05 % w/V), Group III received same as Group II and followed by piperine (50mg/kg b.wt) and Group IV received piperine alone at a dose of 50mg/kg b.wt, up to 16 successive weeks. Results indicated that there is significant increase in relative liver weight (P<0.001) and liver marker enzymes (SGOT, SGPT, ACP, ALP, LDH, gGT, TBIL, Total protein, DNA at P<0.001), tumor marker enzymes (AFP, CEA at P<0.001). also, significant abnormalities were observed in membrane bound enzymes (Ca2+, Na+/K+, Mg2+ ATP age at P<0.001) and electrolytes (Na+, K+ , Ca2+, Mg2+ at P<0.001), whereas the above said alterations were significantly restored in piperine treated groups compared with DEN treated group. The histopathological changes of liver were compared with respective control groups. These findings suggest that piperine can be used as an adjunct to conventional chemo preventive agent, which may provide a novel therapeutic approach to serve as promising agent for treatment of hepatocellular carcinoma.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

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