FORMULATION AND DEVELOPMENT OF LONG-ACTING THERMOSENSITIVE AND MUCOADHESIVE VAGINAL GEL OF METRONIDAZOLE

Abstract

The development of an in situ metronidazole gel that is mucoadhesive and thermo sensitive was the aim of this study in the fight against bacterial vaginosis. Numerous evaluation criteria have been carried out, including mucoadhesive force, pH, viscosity, syringe capability, medication content, gelation temperature, and gelation time. All of the solutions were found to have pH values between 6-7. The viscosity was correlated with the mucoadhesive force. The drug release parameter indicates that in situ gels containing Carbopol 934 provide superior drug release compared to other polymers. Additionally, Carbopol 934 has 118 g more mucoadhesive strength than HEC and HPMC. Compared to non-ionic polymers like HPMC and HEC, Carbopol 934 effectively slows down drug release since it is a cationic polymer. After a 30-day stability test, the gel’s properties barely changed. It follows that the developed formulation of metronidazole in situ gels is more reliable and efficient than earlier vaginal gels.