INVESTIGATION OF SUPERFLUITY POTENTIAL OF BCS-II DRUG BY USING SOLVENT SHIFT METHOD

Abstract

This research work’s motive was to investigate the superfluity potential of the BCS-II drug (Dextromethorphan HBr) by solvent shift method to evaluate the impact of polymer gain factor on superfluity potential for the enhancement of bioavailability of orally prolonged release. To maintain the superfluity potential, different drug-release retarding polymers were used (HPMC 15cps, xanthan gum, sodium CMC) in a bio-relevant medium. The outcomes of this, reveal that all polymers remarkably enhanced the solubility of dextromethorphan HBr 1.07-2.49 fold when compared to those without polymer. HPMC and xanthan gum both at 0.1 % w/V showed excellent precipitation inhibitor's role at about 10.2-22.1 factor in SIFsp and 6.04-6.75 factor in PBS (pH 7.4). Elucidation of these results, show that HPMC (15cps) works on the parachute concept and Xanthan Gum on the glider concept. Hence, the superfluity potential is maintained by the selection of excellent polymers in non-formulated drugs to develop the superfluity formulation.