ENHACEMENT OF SOLUBILITY PROFILE OF PLUMBAGIN CONTAINING TABLET AT DIFFERENT COLONIC REGION FOR COLON TARGETING DRUG DELIVERY SYSTEM

Abstract

The aim of present study is to improve solubility profile of a poorly soluble anti-cancer natural product, plumbagin at colonic site through incorporation of β-cyclodextrin by preparing complexes by a number of methods. Natural compound plumbagin have lower solubility profile in various GIT medias i.e. 0.1 N HCl, at stomach and intestinal pH. Natural compound plumbagin containing β-cyclodextrin complexes prepared with a number of methods increased the solubility profile in different dissolution media. The nature of plumbagin complexes was ascertained by FTIR spectrum. The tablet formulation of plumbagin β-cyclodextrin complex (kneading method) was prepared and coated with pH sensitive polymer Eudragit L100 for colon targeting. Plumbagin β-cyclodextrin complex can be used in place of pure plumbagin for the preparation of colon targeted drug delivery system.