ASSOCIATION OF HYPERTLEPTINEMIA AND GESTATIONAL WEIGHT GAIN

Abstract

The aim of the study was to determine the dynamics of leptin plasma concentration in pregnant women, depending on gestational weight gain. This prospective study included 163 pregnant women who visited antenatal clinics in Ivano-Frankivsk, Ukraine during 2016–2018. The recommended GWG was diagnosed in 56 (34.4 %), insufficient in 33 (20.2 %) and excessive in 74 (45.4 %) patients, according to the recommendations of the Institute of Medicine (IOM) in the USA (2009) and the Order of the Ministry of Health of Ukraine № 417 (2011). Anthropometry, gestational weight gain, percentage of body fat mass and concentration of leptin plasma concentration were performed at the first, second and third trimesters of pregnancy. Statistical analyses were carried out using «Statistica 6.0». We demonstrated the association between elevated levels of leptin and gestational weight gain in all pregnant women in spite of prepregnancy body weight. The strongest dynamics of leptin increase was observed in normal weight women with excessive gestational weight gain: progression of hyperleptinemia during pregnancy was more intensive than in overweight. Higher second trimester leptin levels were positive associated with a greater subsequent weight gain and percentage of body fat mass, especially expressed in excessive weight gain women. The development of leptin resistance in these patients may be as a trigger for postpartum weight retention, overweight and obesity.