Handling Data Below the Limit of Quantification in Mixed Effect Models
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science
Link
http://link.springer.com/content/pdf/10.1208/s12248-009-9112-5.pdf
Reference15 articles.
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2. Duval V, Karlsson MO. Impact of omission or replacement of data below the limit of quantification on parameter estimates in a two-compartment model. Pharm Res 2002;19(12):1835–40.
3. Bergstrand M, Plan E, Kjellsson M, Karlsson MO. A comparison of methods for handling of data below the limit of quantification in NONMEM VI. PAGE 16 (2007) Abstr 1201 [ www.page-meeting.org/?abstract=1201 ].
4. Hing JP, Woolfrey SG, Greenslade D, Wright PM. Analysis of toxicokinetic data using NONMEM: impact of quantification limit and replacement strategies for censored data. J Pharmacokinet Pharmacodyn 2001;28(5):465–79.
5. Beal SL. Ways to fit a PK model with some data below the quantification limit. J Pharmacokinet Pharmacodyn 2001;28(5):481–504.
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