Handling Data Below the Limit of Quantification in Mixed Effect Models-Reference-Cited by-同舟云学术

Handling Data Below the Limit of Quantification in Mixed Effect Models

Published:2009-05-19 Issue:2 Volume:11 Page:371-380
ISSN:1550-7416
Container-title:The AAPS Journal
language:en
Short-container-title:AAPS J

Author:

Bergstrand Martin,Karlsson Mats O.

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Link

http://link.springer.com/content/pdf/10.1208/s12248-009-9112-5.pdf

Reference15 articles.

1. FDA guidance for industry bioanalytical method validation. http://www.fdagov/cder/guidance/4252fnl.pdf (accessed 05/05/2007).

2. Duval V, Karlsson MO. Impact of omission or replacement of data below the limit of quantification on parameter estimates in a two-compartment model. Pharm Res 2002;19(12):1835–40.

3. Bergstrand M, Plan E, Kjellsson M, Karlsson MO. A comparison of methods for handling of data below the limit of quantification in NONMEM VI. PAGE 16 (2007) Abstr 1201 [ www.page-meeting.org/?abstract=1201 ].

4. Hing JP, Woolfrey SG, Greenslade D, Wright PM. Analysis of toxicokinetic data using NONMEM: impact of quantification limit and replacement strategies for censored data. J Pharmacokinet Pharmacodyn 2001;28(5):465–79.

5. Beal SL. Ways to fit a PK model with some data below the quantification limit. J Pharmacokinet Pharmacodyn 2001;28(5):481–504.

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