What is the Likelihood of an Active Compound to Be Promiscuous? Systematic Assessment of Compound Promiscuity on the Basis of PubChem Confirmatory Bioassay Data-Reference-Cited by-同舟云学术

What is the Likelihood of an Active Compound to Be Promiscuous? Systematic Assessment of Compound Promiscuity on the Basis of PubChem Confirmatory Bioassay Data

Published:2013-04-19 Issue:3 Volume:15 Page:808-815
ISSN:1550-7416
Container-title:The AAPS Journal
language:en
Short-container-title:AAPS J

Author:

Hu Ye,Bajorath Jürgen

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Link

http://link.springer.com/content/pdf/10.1208/s12248-013-9488-0.pdf

Reference17 articles.

1. Paolini GV, Shapland RHB, van Hoorn WP, Mason JS, Hopkins AL. Global mapping of pharmacological space. Nat Biotechnol. 2006;24(7):805–15. doi: 10.1038/nbt1228 .

2. Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nat Biotechnol. 2007;25(2):197–206. doi: 10.1038/nbt1284 .

3. Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008;4(11):682–90. doi: 10.1038/nchembio.118 .

4. Mestres J, Gregori-Puigjane E, Valverde S, Sole RV. Data completeness—the achilles heel of drug–target networks. Nat Biotechnol. 2008;26(9):983–4. doi: 10.1038/nbt0908-983 .

5. Knight ZA, Lin H, Shokat KM. Targeting the cancer kinome through polypharmacology. Nat Rev Cancer. 2010;10(2):130–7. doi: 10.1038/nrc2787 .

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A systematic study of key elements underlying molecular property prediction;Nature Communications;2023-10-13

2. Structure, Activation, and Regulation of NOX2: At the Crossroad between the Innate Immunity and Oxidative Stress-Mediated Pathologies;Antioxidants;2023-02-09

3. Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors;European Journal of Medicinal Chemistry;2022-12

4. The Communication of Hit Quality Using Natural History Visualizations (NHVs);SLAS DISCOVERY: Advancing the Science of Drug Discovery;2021-06-11

5. Does In Vitro Potency Predict Clinically Efficacious Concentrations?;Clinical Pharmacology & Therapeutics;2020-05-10