Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1-Reference-Cited by-同舟云学术

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Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1

Published:2019-07-24 Issue:5 Volume:21 Page:
ISSN:1550-7416
Container-title:The AAPS Journal
language:en
Short-container-title:AAPS J

Author:

Hamuro Lora,Tirucherai Giridhar S.,Crawford Sean M.,Nayeem Akbar,Pillutla Renuka C.,DeSilva Binodh S.,Leil Tarek A.,Thalhauser Craig J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Link

http://link.springer.com/content/pdf/10.1208/s12248-019-0361-7.pdf

Reference43 articles.

1. Deehan M, Garces S, Kramer D, Baker MP, Rat D, Roettger Y, et al. Managing unwanted immunogenicity of biologicals. Autoimmun Rev. 2015;14(7):569–74.

2. Baker MP, Reynolds HM, Lumicisi B, Bryson CJ. Immunogenicity of protein therapeutics: the key causes, consequences and challenges. Self Nonself. 2010;1(4):314–22.

3. Moticka EJ. Hallmarks of the adaptive immune response. In: Moticka EJ, editor. A historical perspective on evidence-based immunology. Waltham, MA: Elsevier; 2016. p. 9–19.

4. Chen X, Hickling TP, Vicini P. A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins: part 2-model applications. CPT Pharmacometrics Syst Pharmacol. 2014;3:e134.

5. Chen X, Hickling TP, Vicini P. A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins: part 1-theoretical model. CPT Pharmacometrics Syst Pharmacol. 2014;3:e133.

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