Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar

Author:

Misra Sandeep K.,Orlando Ron,Weinberger Scot R.,Sharp Joshua S.ORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference37 articles.

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2. Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–75. https://doi.org/10.1007/s11095-009-0045-6 .

3. Giezen TJ, Mantel-Teeuwisse AK, Strauss S. Safety-related regulatory actions for biologicals approved in the United States and the European Union. J Am Med Soc. 2008;300(16):1887–96.

4. Giezen TJ, Schneider CK. Safety assessment of biosimilars in Europe: a regulatory perspective. Generics Biosimilars Initiat J. 2014;2014:1–8.

5. Buxton GV, Greenstock CL, Helman WP, Ross AB. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (.OH/.O-) in aqueous solution. J Phys Chem Ref Data. 1988;17(2):513–886.

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