Effect of the Plasticizer DEHP in Blood Collection Bags on Human Plasma Fraction Unbound Determination for Alpha-1-Acid Glycoprotein (AAG) Binding Drugs

Author:

Ingram Nicholas,Dishinger Christopher,Wood Jennifer,Hutzler J. Matthew,Smith Sherri,Huskin Michael

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference23 articles.

1. Brown K, Hingorani G, Franklin R. An effective screening approach to assess the impact of α-1 acid glycoprotein binding on the fraction unbound of a drug. Poster session presented at: 17th Annual ISSX Meeting; 2011. Oct 16–20; Atlanta GA.

2. Routledge PA. The plasma protein binding of basic drugs. Br J Clin Pharmacol. 1986;22(5):499–506.

3. Al-Dewik N, Jewell A, Yassin M, Morsi H. Studying the impact of presence of alpha acid glycoprotein and protein glycoprotein in chronic myeloid leukemia patients treated with Imatinib Mesylate in the State of Qatar. Biomark Cancer. 2015;7:63–7.

4. Pollack GM, Buchanan JF, Slaughter RL, Kohli RK, Shen DD. Circulating concentrations of di(2-ethylhexyl) phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis. Toxicol Appl Pharmacol. 1985;79(2):257–67.

5. Bicalho B, Serrano K, dos Santos Pereira A, Devine DV, Acker JP. Blood bag plasticizers influence red blood cell vesiculation rate without altering the lipid composition of the vesicles. Transfus Med Hemother. 2016;43:19–26. https://doi.org/10.1159/000441639 .

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