The Role of Model Master Files for Sharing, Acceptance, and Communication with FDA

Author:

Fang Lanyan,Gong Yuqing,Hooker Andrew C.,Lukacova Viera,Rostami-Hodjegan Amin,Sale Mark,Grosser Stella,Jereb Rebeka,Savic Rada,Peck Carl,Zhao LiangORCID

Publisher

Springer Science and Business Media LLC

Reference20 articles.

1. FDA-CRCG public workshop: best practices for utilizing modeling approaches to support generic product development, October 27-28, 2022, Virtual Workshop. Available from: https://www.complexgenerics.org/education-training/best-practices-for-utilizing-modeling-approaches-to-support-generic-product-development/. Accessed 10 Feb 2024.

2. Babiskin A, et al. Regulatory utility of mechanistic modeling to support alternative bioequivalence approaches: a workshop overview. CPT Pharmacomet Syst Pharmacol. 2023;12(5):619-623. https://doi.org/10.1002/psp4.12920.

3. Zhao L. What Is a model master file and how can it be shared? FDA-CRCG Public workshop: regulatory utility of mechanistic modeling to support alternative bioequivalence approaches: regulatory utility of mechanistic modeling to support alternative bioequivalence approaches, September 30 and October 1, 2021, Virtual Workshop. Available from: https://www.complexgenerics.org/education-training/regulatory-utility-of-mechanistic-modeling-to-support-alternative-bioequivalence-approaches/. Accessed 10 Feb 2024.

4. Tsakalozou E, Babiskin A, Zhao L. Physiologically-based pharmacokinetic modeling to support bioequivalence and approval of generic products: a case for diclofenac sodium topical gel, 1. CPT Pharmacometrics Syst Pharmacol. 2021;10(5):399–411.

5. Guidance for industry: bioequivalence studies with pharmacokinetic endpoints for drugs submitted under an ANDA (August 2021). Available from: https://www.fda.gov/media/87219/download. Accessed 10 Feb 2024.

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