Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (II): In vitro evaluation of efficacy and toxicity

Author:

Chang Li-Chien,Liang Jun Feng,Lee Hsiao-Feng,Lee Lai Ming,Yang Victor C

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference25 articles.

1. Jones GR, Hashim R, Power DM. A comparison of the strength of binding of antithrombin III, protamine and poly(1-lysine) to heparin samples of different anticoagulant activities. Biochim Biophys Acta. 1986;883:69–76.

2. Metz S, Horrow JC. Protamine and newer heparin antagonists. In: Stoelting RK. ed. Pharmacology & Physiology in Anesthetic Practice. JB Lippincott Co. Philadelphia, PA. 1994:1–15.

3. Porsche R, Brenner ZR. Allergy to protamine sulfate. Heart Lung. 1999;28:418–428.

4. Weiler JM, Gellhaus MA, Carter JG, et al. A prospective study of the risk of an immediate adverse reaction to protamine sulfate during cardiopulmonary bypass surgery. J Allergy Clin Immunol. 1990;85:713–719.

5. Levy JH, Zaidan JR, Faraj B. Prospective evaluation of risk of protamine reactions in patients with NPH insulin-dependent diabetes. Anesth Analg. 1986;65:739–742.

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