Discriminating Ability of Abbreviated Impactor Measurement Approach (AIM) to Detect Changes in Mass Median Aerodynamic Diameter (MMAD) of an Albuterol/Salbutamol pMDI Aerosol

Author:

David Christopher J .,Patel Rajni B.,Mitchell Jolyon P.,Tougas Terrence P.,Goodey Adrian P.,Quiroz Jorge,Andersson Patrik U.,Lyapustina Svetlana

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmaceutical Science,Agronomy and Crop Science,Ecology,Aquatic Science,General Medicine,Ecology, Evolution, Behavior and Systematics

Reference32 articles.

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2. FDA, CDER. Draft guidance for industry. metered dose inhaler (MDI) and dry powder inhaler (DPI) drug products chemistry, manufacturing, and controls documentation. 1998. www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm070573.pdf Accessed 31 Mar 2016.

3. Mitchell JP, Nagel MW. Cascade impactors for the size characterization of aerosols from medical inhalers. Their uses and limitations. J Aerosol med. 2003;16(4):341–77.

4. Marple VA, Liu BYH. Characteristics of laminar jet impactors. Environ Sci Technol. 1974;8:648–54.

5. Christopher D, Curry P, Doub W, Furnkranz K, Lavery M, Lin K, et al. Considerations for the development and practice of cascade impaction testing including a mass balance failure investigation tree. J Aerosol med. 2003;16(3):235–47.

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