Evaluation of the Sensitivity and Robustness of Modified Chi-Square Ratio Statistic for Cascade Impactor Equivalence Testing Through Monte Carlo Simulations

Author:

Kurumaddali Abhinav,Christopher David,Strickland Helen,Morgan Beth,Wiggenhorn Christopher,Stein Stephen,Lyapustina Svetlana,Hochhaus Günther

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmaceutical Science,Agronomy and Crop Science,Ecology,Aquatic Science,General Medicine,Ecology, Evolution, Behavior and Systematics

Reference14 articles.

1. Lu D, Lee SL, Lionberger RA, Choi S, Adams W, Caramenico HN, et al. International guidelines for bioequivalence of locally acting orally inhaled drug products: similarities and differences. AAPS J. 2015;17(3):546–57 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25758352. Accessed 27 April 2020.

2. Morgan B, Strickland H. Performance properties of the population bioequivalence approach for in vitro delivered dose for orally inhaled respiratory products. AAPS J. 2014;16(1):89–100 Available from: http://www.ncbi.nlm.nih.gov/pubmed/24249218. Accessed 27 April 2020.

3. Sandell D, Mitchell JP. Considerations for designing in vitro bioequivalence (IVBE) studies for pressurized metered dose inhalers (pMDIs) with spacer or valved holding chamber (S/VHC) add-on devices. J Aerosol Med Pulm Drug Deliv. 2014;27(0):1–26 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25089555. Accessed 27 April 2020.

4. Kurumaddali A, Christopher D, Sandell D, Strickland H, Morgan B, Bulitta J, et al. Cascade impactor equivalence testing: comparison of the performance of the modified chi-square ratio statistic (mCSRS) with the original CSRS and EMA’s average bioequivalence approach. AAPS PharmSciTech. 2019;20(6):249 Available from: http://link.springer.com/10.1208/s12249-019-1443-7. Accessed 27 April 2020.

5. Weber B, Hochhaus G, Adams W, Lionberger R, Li B, Tsong Y, et al. A stability analysis of a modified version of the chi-square ratio statistic: implications for equivalence testing of aerodynamic particle size distribution. AAPS J. 2013 [cited 2015 May 2];15(1):1–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3535092&tool=pmcentrez&rendertype=abstract.

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