Optimization and Evaluation of Gastroretentive Ranitidine HCl Microspheres by Using Factorial Design with Improved Bioavailability and Mucosal Integrity in Ulcer Model

Author:

Khattab Abeer,Zaki Nashwah

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmaceutical Science,Agronomy and Crop Science,Ecology,Aquatic Science,General Medicine,Ecology, Evolution, Behavior and Systematics

Reference74 articles.

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2. Wallace JL, Granger DN. The cellular and molecular basis of gastric mucosal defense. FASEB J. 1996;10(7):731–40.

3. Bourdet DL, Pritchard JB, Thakker DR. Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther. 2005;315(3):1288–90.

4. Chavda H, Patel C. Chitosan superporous hydrogel composite-based floating drug delivery system: a newer formulation approach. J Pharm Bioall Sci. 2010;2:124–31.

5. Novak KM. Histamine H2 antagonists. In: Novak KM, editor. Drug facts and comparisons. 56th ed. MO: St. Louis; 2002. p. 1192–7.

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