Genes and Protein Synthesis—Updating Our Understanding

Author:

Brady Timothy P.1

Affiliation:

1. TIMOTHY BRADY (timbra717@yahoo.com) has been a science teacher at North Hollywood High School in Los Angeles since 2001.

Abstract

That genes are indispensable is indisputable but that they are the source of information for protein synthesis—to the extent reflected by statements such as “genes are blueprints for proteins” or “genomes constitute developmental programs”—is challenged by discoveries such as post-translational modification of protein and alternative splicing.

Publisher

University of California Press

Subject

General Agricultural and Biological Sciences,Agricultural and Biological Sciences (miscellaneous),Education

Reference39 articles.

1. There is more than one type of AS. The type illustrated here, exon skipping, is the most common.

2. I recommend Evelyn Fox Keller's very readable The Century of the Gene for a much broader examination of the factors driving modern biology's growing recognition of the limitations of genetic reductionism.

3. Influence of RNA secondary structure on the pre-mRNA splicing process;Molecular and Cellular Biology,2004

4. Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches;Nature Reviews. Molecular Cell Biology,2009

5. Chen, X., Shi, S.-P., Xu, H.-D., Suo, S.-B., & Qiu, J.-D. (2016). A homology-based pipeline for global prediction of post-translational modification sites. Scientific Reports, 6, 25801. doi:10.1038/srep 25801

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