Purpose and Benefits of Early Phase Cancer Trials: What Do Oncologists Say? What Do Patients Hear?

Author:

Kass Nancy,Taylor Holly,Fogarty Linda1,Sugarman Jeremy,Goodman Steven N.,Goodwin-Landher Annallys2,Carducci Michael3,Hurwitz Herbert2

Affiliation:

1. JHPIEGO

2. Duke University Medical Center

3. Johns Hopkins School of Medicine

Abstract

Cancer patients overestimate benefits of early phase trials but studies have not reported what oncologists say to patients about trials. We audiotaped oncologists talking to cancer patients about Phase I or II trials and interviewed patients about the purpose and expected outcomes of trials presented to them. Oncologists gave mixed messages, saying Phase I trials measure safety and dosing, yet referring to trials as treatment with uncertain therapeutic effects. Seventeen percent of Phase I respondents said the trials purpose related to safety/dosing ( p = 0.017); 17% of Phase I respondents said the purpose was “to cure my cancer.” Patients may find it important to believe trials offer significant benefit. Oncologists, while respecting patients' hopes, should be precise in their language, particularly regarding Phase I trials, distinguishing early stages of research from treatment.

Publisher

SAGE Publications

Subject

Communication,Education,Social Psychology

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