Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition-Reference-Cited by-同舟云学术

Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition

Published:2018-01-15 Issue:2 Volume:197 Page:244-260
ISSN:1073-449X
Container-title:American Journal of Respiratory and Critical Care Medicine
language:en
Short-container-title:Am J Respir Crit Care Med

Author:

Zabini Diana¹²,Granton Elise¹,Hu Yijie¹,Miranda Maria Zena¹,Weichelt Ulrike³,Breuils Bonnet Sandra⁴,Bonnet Sébastien⁴,Morrell Nicholas W.⁵,Connelly Kim A.¹,Provencher Steeve⁴,Ghanim Bahil⁶,Klepetko Walter⁶,Olschewski Andrea²,Kapus Andras¹⁷,Kuebler Wolfgang M.¹³⁷

Affiliation:

1. Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, Ontario, Canada

2. Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria

3. Department of Physiology, Charité-Universitätsmedizin Berlin, Berlin, Germany

4. Pulmonary Hypertension Group of the Institute of Cardiology and Pulmonology, Laval University, Quebec City, Québec, Canada

5. Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom

6. Department of Thoracic Surgery, Medical University, Vienna, Austria; and

7. Department of Surgery, University of Toronto, Toronto, Ontario, Canada

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Link

http://www.atsjournals.org/doi/pdf/10.1164/rccm.201702-0386OC

Reference50 articles.

1. Hypoxia-Induced Pulmonary Vascular Remodeling

2. Cellular and molecular pathobiology of pulmonary arterial hypertension

3. Clinical and Molecular Genetic Features of Pulmonary Hypertension in Patients with Hereditary Hemorrhagic Telangiectasia

4. Mutation in the Gene for Bone Morphogenetic Protein Receptor II as a Cause of Primary Pulmonary Hypertension in a Large Kindred

5. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension

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