B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis

Author:

Bénard Alan123,Sakwa Imme4,Schierloh Pablo25,Colom André12,Mercier Ingrid126,Tailleux Ludovic78,Jouneau Luc9,Boudinot Pierre9,Al-Saati Talal10,Lang Roland11,Rehwinkel Jan12,Loxton Andre G.13,Kaufmann Stefan H. E.14,Anton-Leberre Véronique6,O’Garra Anne1516,Sasiain Maria Del Carmen25,Gicquel Brigitte9,Fillatreau Simon4171819,Neyrolles Olivier12,Hudrisier Denis12

Affiliation:

1. Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, Centre National de la Recherche Scientifique (CNRS), Université Paul Sabatier, Toulouse, France

2. International Associated Laboratory CNRS “IM-TB/HIV (Immunometabolism and Macrophages in Tuberculosis/Human Immunodeficiency Virus-1 Co-infection),” Toulouse, France, and Buenos Aires, Argentina

3. Department of Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Germany

4. Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Berlin, Germany

5. Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas, Academia Nacional de Medicina, Pacheco de Melo, Buenos Aires, Argentina

6. Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés, Université de Toulouse, CNRS, Institut National de la Recherche Agronomique (INRA), Institut National des Sciences Appliquées, Toulouse, France

7. Unit of Mycobacterial Genetics and

8. Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Paris, France

9. Virologie et Immunologie Moléculaires, INRA, Jouy-en-Josas, France

10. Institut National de la Santé et de la Recherche Médicale (INSERM)/Université Paul Sabatier/École Nationale Vétérinaire de Toulouse/Centre Régional d’Exploration Fonctionnelle et Ressources Expérimentales, Service d’Histopathologie, Centre Hospitalier Universitaire, Purpan, Toulouse, France

11. Institute of Clinical Microbiology, Immunology, and Hygiene, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

12. Radcliffe Department of Medicine, Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

13. South African Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, South Africa

14. Department of Immunology, Max Planck Institute of Infection Biology, Berlin, Germany

15. Division of Immunoregulation, Medical Research Council, National Institute for Medical Research, London, United Kingdom

16. National Heart and Lung Institute, Imperial College London, London, United Kingdom

17. Institut Necker-Enfants Malades, INSERM U1151-CNRS Unité Mixte de Recherche 8253, Paris, France

18. Université Paris Descartes, Sorbonne Paris Cité, Paris, France; and

19. Assistance Publique–Hôpitaux de Paris, Hôpital Necker Enfants Malades, Paris, France

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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