Respirable Crystalline Silica Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Analysis of Case–Control Studies

Author:

Ge Calvin1ORCID,Peters Susan1,Olsson Ann2,Portengen Lützen1,Schüz Joachim2,Almansa Josué1,Behrens Thomas3,Pesch Beate3,Kendzia Benjamin3,Ahrens Wolfgang4,Bencko Vladimir5,Benhamou Simone6,Boffetta Paolo78,Bueno-de-Mesquita Bas9,Caporaso Neil10,Consonni Dario11,Demers Paul12,Fabiánová Eleonóra1314,Fernández-Tardón Guillermo15,Field John16,Forastiere Francesco17,Foretova Lenka18,Guénel Pascal19,Gustavsson Per20,Ho Vikki21,Janout Vladimir22,Jöckel Karl-Heinz23,Karrasch Stefan242526,Landi Maria Teresa10,Lissowska Jolanta27,Luce Danièle28,Mates Dana29,McLaughlin John30,Merletti Franco31,Mirabelli Dario31,Plato Nils20,Pohlabeln Hermann4,Richiardi Lorenzo31,Rudnai Peter32,Siemiatycki Jack21,Świątkowska Beata33,Tardón Adonina15,Wichmann Heinz-Erich3435,Zaridze David36,Brüning Thomas3,Straif Kurt2,Kromhout Hans1,Vermeulen Roel1

Affiliation:

1. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands

2. International Agency for Research on Cancer (IARC), World Health Organization (WHO), Lyon, France

3. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance-Institute of the Ruhr University, Bochum, Germany

4. Leibniz Institute for Prevention Research and Epidemiology-Bremen Institute for Prevention Research and Social Medicine (BIPS), Bremen, Germany

5. Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Prague, Czech Republic

6. Inserm Unit 1018, Villejuif, France

7. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York

8. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

9. The National Institute for Public Health and Environmental Protection, Bilthoven, the Netherlands

10. National Cancer Institute, Bethesda, Maryland

11. Unità di epidemiologia, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

12. Occupational Cancer Research Centre, Cancer Care Ontario, Toronto, Ontario, Canada

13. Regional Authority of Public Health, Banská Bystrica, Slovakia

14. Faculty of Health, Catholic University, Ružomberok, Slovakia

15. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Institute of Health Research of the Principality of Asturias-Foundation for Biosanitary Research of Asturias (ISPA-FINBA), Faculty of Medicine, University of Oviedo, Oviedo, Spain

16. Roy Castle Lung Cancer Research Programme, Cancer Research Centre, University of Liverpool, Liverpool, United Kingdom

17. Consiglio Nazionale delle Ricerche-Istituto per la Ricerca e l’Innovazione Biomedica (CNR-Irib), Palermo, Italy

18. Masaryk Memorial Cancer Institute, Brno, Czech Republic

19. Center for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, Inserm Unit 1018, University Paris-Saclay, Villejuif, France

20. The Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden

21. University of Montreal Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada

22. Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic

23. Institute for Medical Informatics, Biometry, and Epidemiology, University of Duisburg-Essen, Essen, Germany

24. Institute and Outpatient Clinic for Occupational, Social, and Environmental Medicine, Inner City Clinic, University Hospital of Munich and

25. Institute of Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany

26. Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Neuherberg, Germany

27. The M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

28. Université de Rennes I, Inserm Unit 1085, École des hautes études en santé publique (EHESP), Institut de recherche en santé, environnement et travail (Irset), Pointe-à-Pitre, France

29. National Institute of Public Health, Bucharest, Romania

30. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

31. Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Torino, Italy

32. National Public Health Center, Budapest, Hungary

33. The Nofer Institute of Occupational Medicine, Lodz, Poland

34. Institut für Medizinische Informatik Biometrie Epidemiologie, Ludwig-Maximilians-Universität, Munich, Germany

35. Institut für Epidemiologie, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany; and

36. Russian Cancer Research Centre, Moscow, Russia

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Reference28 articles.

1. U.S. National Toxicological Program. Silica, crystalline (respirable size): report on carcinogens, 14th ed. Research Triangle Park, NC.: National Toxicology Program; 2016.

2. Exposure-Response Analysis and Risk Assessment for Lung Cancer in Relationship to Silica Exposure: A 44-Year Cohort Study of 34,018 Workers

3. Quantitative relationship between silica exposure and lung cancer mortality in German uranium miners, 1946–2003

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