1. Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom
2. Centre for Perioperative and Critical Care Research, Imperial College Healthcare National Health Service Trust, London, United Kingdom
3. Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
4. Imperial Clinical Trials Unit, Faculty of Medicine, Imperial College London, London, United Kingdom; and
5. Intensive Care Unit, Barts and the London, Queen Mary School of Medicine, London, United Kingdom