IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

Author:

Harris Alison J.1,Mirchandani Ananda S.1,Lynch Ruairi W.1,Murphy Fiona1,Delaney Liam1,Small Donna2,Coelho Patricia1,Watts Emily R.1,Sadiku Pranvera1,Griffith David1ORCID,Dickinson Rebecca S.1,Clark Eilidh1,Willson Joseph A.1,Morrison Tyler1,Mazzone Massimilliano3,Carmeliet Peter4,Ghesquiere Bart4,O’Kane Cecilia2,McAuley Danny2,Jenkins Steve J.1,Whyte Moira K. B.1,Walmsley Sarah R.1ORCID

Affiliation:

1. Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

2. School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen’s University of Belfast, Belfast, United Kingdom

3. Laboratory of Tumour Inflammation and Angiogenesis, Department of Oncology, Leuven, Belgium; and

4. Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, Leuven, Belgium

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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