SPX-101 Is a Novel Epithelial Sodium Channel–targeted Therapeutic for Cystic Fibrosis That Restores Mucus Transport-Reference-Cited by-同舟云学术

SPX-101 Is a Novel Epithelial Sodium Channel–targeted Therapeutic for Cystic Fibrosis That Restores Mucus Transport

Published:2017-09-15 Issue:6 Volume:196 Page:734-744
ISSN:1073-449X
Container-title:American Journal of Respiratory and Critical Care Medicine
language:en
Short-container-title:Am J Respir Crit Care Med

Author:

Scott David W.¹,Walker Matthew P.¹,Sesma Juliana¹,Wu Bryant¹,Stuhlmiller Timothy J.¹,Sabater Juan R.²,Abraham William M.²,Crowder Timothy M.¹,Christensen Dale J.¹,Tarran Robert¹³⁴

Affiliation:

1. Spyryx Biosciences, Durham, North Carolina

2. Department of Research, Mount Sinai Medical Center, Miami Beach, Florida; and

3. Marsico Lung Institute and

4. Department of Cell Biology and Physiology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Link

http://www.atsjournals.org/doi/pdf/10.1164/rccm.201612-2445OC

Reference49 articles.

1. CFTR Function and Prospects for Therapy

2. Sodium Channels and Cystic Fibrosis

3. Relative ion permeability of normal and cystic fibrosis nasal epithelium.

4. Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration

5. ENaC Inhibitors and Airway Re-hydration in Cystic Fibrosis: State of the Art

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