1. Translational Medicine
2. Department of Critical Care Medicine, and
3. Department of Anesthesia, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
4. Intensive Care Unit, Osaka University Hospital, Suita, Japan; and
5. Laboratório de Pneumologia LIM-09, Disciplina de Pneumologia, Heart Institute (InCor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil