Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis

Author:

Dheda Keertan12,Lenders Laura1,Magombedze Gesham3,Srivastava Shashikant3,Raj Prithvi4,Arning Erland5,Ashcraft Paula5,Bottiglieri Teodoro5,Wainwright Helen6,Pennel Timothy7,Linegar Anthony7,Moodley Loven7,Pooran Anil1,Pasipanodya Jotam G.3,Sirgel Frederick A.8,van Helden Paul D.8,Wakeland Edward4,Warren Robin M.8,Gumbo Tawanda13ORCID

Affiliation:

1. Center for Lung Infection and Immunity, Division of Pulmonology and University of Cape Town Lung Institute, Department of Medicine

2. Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

3. Center for Infectious Diseases Research and Experimental Therapeutics and

4. Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas

5. Institute of Metabolic Disease, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas

6. Department of Pathology and

7. Chris Barnard Division of Cardiothoracic Surgery, Department of Surgery, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa

8. Division of Molecular Biology and Human Genetics, South African Medical Research Council Centre for Tuberculosis Research/Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Stellenbosch, South Africa

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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