A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED-Reference-Cited by-同舟云学术

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED

Published:2017-02-15 Issue:4 Volume:195 Page:443-455
ISSN:1073-449X
Container-title:American Journal of Respiratory and Critical Care Medicine
language:en
Short-container-title:Am J Respir Crit Care Med

Author:

Kuo Chih-Hsi Scott¹²³,Pavlidis Stelios¹²⁴,Loza Matthew⁴,Baribaud Fred⁴,Rowe Anthony⁴,Pandis Ioannis¹²,Hoda Uruj³⁵,Rossios Christos³,Sousa Ana⁶,Wilson Susan J.⁷,Howarth Peter⁷,Dahlen Barbro⁸,Dahlen Sven-Erik⁸,Chanez Pascal⁹,Shaw Dominick¹⁰,Krug Norbert¹¹,Sandstrӧm Thomas¹²,De Meulder Bertrand¹³,Lefaudeux Diane¹³,Fowler Stephen¹⁴,Fleming Louise³⁵,Corfield Julie¹⁵¹⁶,Auffray Charles¹³,Sterk Peter J.¹⁷,Djukanovic Ratko⁷,Guo Yike¹²,Adcock Ian M.³⁵,Chung Kian Fan³⁵

Affiliation:

1. Department of Computing

2. Data Science Institute, and

3. Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom

4. Janssen Research and Development, High Wycombe, United Kingdom

5. Biomedical Research Unit, Royal Brompton & Harefield National Health Service Trust, London, United Kingdom

6. Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, United Kingdom

7. Faculty of Medicine, Southampton University, Southampton, United Kingdom

8. Centre for Allergy Research, Karolinska Institute, Stockholm, Sweden

9. Université de la Méditerranee, Marseille, France

10. Centre for Respiratory Research, University of Nottingham, Nottingham, United Kingdom

11. Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany

12. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

13. European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, University of Lyon, Lyon, France

14. Centre for Respiratory Medicine and Allergy, University of Manchester, Manchester, United Kingdom

15. AstraZeneca R&D, Molndal, Sweden

16. Areteva R&D, Nottingham, United Kingdom; and

17. Faculty of Medicine, University of Amsterdam, Amsterdam, the Netherlands

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Reference45 articles.

1. Pathobiology of Severe Asthma

2. Increases in Activated T Lymphocytes, Eosinophils, and Cytokine mRNA Expression for Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor in Bronchial Biopsies after Allergen Inhalation Challenge in Atopic Asthmatics

3. Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma

4. T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

5. Assessment of T lymphocyte cytokine production in induced sputum from asthmatics: a flow cytometry study

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