Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study-Reference-Cited by-同舟云学术

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

Published:2021-01-01 Issue:1 Volume:203 Page:37-53
ISSN:1073-449X
Container-title:American Journal of Respiratory and Critical Care Medicine
language:en
Short-container-title:Am J Respir Crit Care Med

Author:

Kolmert Johan¹²³^ORCID,Gómez Cristina¹²³,Balgoma David¹²³,Sjödin Marcus¹²³,Bood Johan¹³⁴,Konradsen Jon R.³⁵⁶,Ericsson Magnus⁷,Thörngren John-Olof⁷,James Anna¹³,Mikus Maria¹³^ORCID,Sousa Ana R.⁸,Riley John H.⁸,Bates Stewart⁸,Bakke Per S.⁹,Pandis Ioannis¹⁰,Caruso Massimo¹¹¹²,Chanez Pascal¹³,Fowler Stephen J.¹⁴,Geiser Thomas¹⁵,Howarth Peter¹⁶,Horváth Ildikó¹⁷,Krug Norbert¹⁸,Montuschi Paolo¹⁹,Sanak Marek²⁰,Behndig Annelie²¹,Shaw Dominick E.²²,Knowles Richard G.²³,Holweg Cécile T. J.²⁴,Wheelock Åsa M.²⁵^ORCID,Dahlén Barbro³⁴,Nordlund Björn⁵⁶,Alving Kjell²⁶,Hedlin Gunilla³⁵⁶,Chung Kian Fan¹⁰,Adcock Ian M.¹⁰^ORCID,Sterk Peter J.²⁷,Djukanovic Ratko¹⁶,Dahlén Sven-Erik¹³^ORCID,Wheelock Craig E.²³^ORCID,Ahmed H.,Auffray C.,Bansal A. T.,Bel E. H.,Bigler J.,Billing B.,Baribaud F.,Bisgaard H.,Boedigheimer M. J.,Bønnelykke K.,Brandsma J.,Brinkman P.,Bucchioni E.,Burg D.,Bush A.,Chaiboonchoe A.,Compton C. H.,Corfield J.,Cunoosamy D.,D’Amico A.,De Meulder B.,Erpenbeck V. J.,Erzen D.,Fichtner K.,Fitch N.,Fleming L. J.,Formaggio E.,Frey U.,Gahlemann M.,Goss V.,Guo Y.,Hashimoto S.,Haughney J.,Hekking P. W.,Higenbottam T.,Hohlfeld J. M.,Knox A. J.,Lazarinis N.,Lefaudeux D.,Loza M. J.,Lutter R.,Manta A.,Masefield S.,Matthews J. G.,Mazein A.,Meiser A.,Middelveld R. J. M.,Miralpeix M.,Mores N.,Murray C. S.,Musial J.,Myles D.,Pahus L.,Pavlidis S.,Postle A.,Powel P.,Praticò G.,PuigValls M.,Rao N.,Roberts A.,Roberts G.,Rowe A.,Sandström T.,Schofield J. P. R.,Seibold W.,Selby A.,Sigmund R.,Singer F.,Skipp P. J.,Smicker M.,Sun K.,Thornton B.,Uddin M.,van Aalderen W. M.,van Geest M.,Vestbo J.,Vissing N. H.,Wagener A. H.,Wagers S. S.,Weiszhart Z.,Wilson S. J.,Östling J.,Ahmed H.,Auffray C.,Bansal A. T.,Bel E. H.,Bigler J.,Billing B.,Baribaud F.,Bisgaard H.,Boedigheimer M. J.,Bønnelykke K.,Brandsma J.,Brinkman P.,Bucchioni E.,Burg D.,Bush A.,Chaiboonchoe A.,Compton C. H.,Corfield J.,Cunoosamy D.,D’Amico A.,De Meulder B.,Erpenbeck V. J.,Erzen D.,Fichtner K.,Fitch N.,Fleming L. J.,Formaggio E.,Frey U.,Gahlemann M.,Goss V.,Guo Y.,Hashimoto S.,Haughney J.,Hekking P. W.,Higenbottam T.,Hohlfeld J. M.,Knox A. J.,Lazarinis N.,Lefaudeux D.,Loza M. J.,Lutter R.,Manta A.,Masefield S.,Matthews J. G.,Mazein A.,Meiser A.,Middelveld R. J. M.,Miralpeix M.,Mores N.,Murray C. S.,Musial J.,Myles D.,Pahus L.,Pavlidis S.,Postle A.,Powel P.,Praticò G.,PuigValls M.,Rao N.,Roberts A.,Roberts G.,Rowe A.,Sandström T.,Schofield J. P. R.,Seibold W.,Selby A.,Sigmund R.,Singer F.,Skipp P. J.,Smicker M.,Sun K.,Thornton B.,Uddin M.,van Aalderen W. M.,van Geest M.,Vestbo J.,Vissing N. H.,Wagener A. H.,Wagers S. S.,Weiszhart Z.,Wilson S. J.,Östling J.

Affiliation:

1. The Institute of Environmental Medicine

2. Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics

3. The Center for Allergy Research

4. Department of Women’s and Children’s Health, and

5. Respiratory Medicine Unit, Department of Medicine, Solna Campus, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

6. Department of Medicine and

7. Department of Clinical Pharmacology, Huddinge Campus, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

8. Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden

9. GlaxoSmithKline, London, United Kingdom

10. Institute of Medicine, University of Bergen, Bergen, Norway

11. National Heart and Lung Institute and Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom

12. Department of Clinical and Experimental Medicine and

13. Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

14. Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Assistance Publique des Hôpitaux de Marseille, Marseille, France

15. Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, and Manchester Academic Health Science Centre and National Institute for Health Research Biomedical Research Centre, Manchester University Hospitals National Health Service Foundation Trust, Manchester, United Kingdom

16. Department of Pulmonary Medicine, University Hospital Bern, Bern, Switzerland

17. Faculty of Medicine, Southampton University, and National Institute for Health Research Southampton Respiratory Biomedical Research Center, University Hospital Southampton, Southampton, United Kingdom

18. Department of Pulmonology, Semmelweis University, Budapest, Hungary

19. Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

20. Department of Pharmacology, Catholic University of the Sacred Heart, and Agostino Gemelli University Hospital Foundation, IRCCS, Rome, Italy

21. Department of Internal Medicine, Medical College, Jagiellonian University, Cracow, Poland

22. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

23. Nottingham National Institute for Health Research Biomedical Research Centre, University of Nottingham, United Kingdom

24. Knowles Consulting, Stevenage Bioscience Catalyst, Stevenage, United Kingdom

25. Genentech Inc., South San Fransisco, California

26. Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; and

27. Department of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Reference49 articles.

1. Asthma

2. Toward clinically applicable biomarkers for asthma: An EAACI position paper

3. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

4. Eicosanoid storm in infection and inflammation

5. Leukotrienes are potent constrictors of human bronchi

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