Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis Associated Pulmonary Arterial Hypertension: A Multi-center, Double-blind, Randomized, Placebo-controlled Trial

Author:

Zamanian Roham T1,Badesch David2,Chung Lorinda34,Domsic Robyn T.5,Medsger Thomas6,Pinckney Ashley7,Keyes-Elstein Lynette7,D'Aveta Carla7,Spychala Meagan7,White R. James8ORCID,Hassoun Paul M9,Torres Fernando10,Sweatt Andrew J1112,Molitor Jerry A.13,Khanna Dinesh14,Maecker Holden15,Welch Beverly16,Goldmuntz Ellen16,Nicolls Mark R17,

Affiliation:

1. Stanford University Medical Center, Department of Medicine, Stanfod, California, United States;

2. University of Colorado, Medicine, Aurora, Colorado, United States

3. Stanford University School of Medicine, Medicine/Rheumatology, Palo Alto, California, United States

4. Palo Alto VA Health Care System, Medicine/Rheumatology, Palo Alto, California, United States

5. University of Pittsburgh School of Medicine, 12317, Pittsburgh, Pennsylvania, United States

6. University of Pittsburgh, 6614, Division of Rheumatology and Clinical Immunology, Pittsburgh, Pennsylvania, United States

7. Rho, Federal Systems Division, Durham, North Carolina, United States

8. University of Rochester, Pulmonary & Critical Care Medicine, Rochester, New York, United States

9. Johns Hopkins University School of Medicine, Medicine - Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States

10. UT Southwestern, Medicine, Dallas, Texas, United States

11. Stanford University, 6429, Medicine - Pulmonary and Critical Care, Stanford, California, United States

12. Stanford University Vera Moulton Wall Center for Pulmonary Vascular Disease, 481207, Stanford, California, United States

13. University of Minnesota, 5635, Minneapolis, Minnesota, United States

14. University of Michigan, 1259, Ann Arbor, Michigan, United States

15. Stanford University School of Medicine, 10624, Stanford, California, United States

16. NIAID DIR, 469049, Bethesda, Maryland, United States

17. VA Palo Alto, Stanford University, Medicine, Palo Alto, California, United States

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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