High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial

Author:

Di Fenza Raffaele12ORCID,Shetty Naman S.3,Gianni Stefano12ORCID,Parcha Vibhu3,Giammatteo Valentina12,Safaee Fakhr Bijan12,Tornberg Daniel45,Wall Olof46,Harbut Piotr45,Lai Peggy S.72ORCID,Li Jonathan Z.28,Paganoni Sabrina9102,Cenci Stefano12,Mueller Ariel L.1112,Houle Timothy T.1112,Akeju Oluwaseun12,Bittner Edward A.12,Bose Somnath212,Scott Louie K.13,Carroll Ryan W.142ORCID,Ichinose Fumito1152,Hedenstierna Magnus16,Arora Pankaj3,Berra Lorenzo115172ORCID,Morais Caio C. Araujo,Gibson Lauren E.,Ikeda Takamitsu,Marutani Eizo,Miyazaki Yusuke,Fischbach Anna,Traeger Lisa,Capriles Martin I.,Delgado Eduardo Diaz,Larson Grant M.,Santiago Roberta Ribeiro De Santis,Vita Carolyn La,Yu Binglan,Cereda Maurizio F.,Greene Nattaly,Restrepo Paula,Flynn James P.,Regan James,Pinciroli Riccardo,Caskey Elizabeth I.,Hutchinson Kimberley,Harris N. Stuart,Rodriguez-Lopez Josanna,Chang Marvin G.,Wideaus Jacob,Widaeus Matilda,Shahgaldi Kambiz,Hagman Karl,Arora Garima,Johnson Robert

Affiliation:

1. Department of Anesthesia, Critical Care, and Pain Medicine,

2. Harvard Medical School, Boston, Massachusetts;

3. Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama;

4. Department of Clinical Sciences and

5. Department of Anesthesia and Intensive Care and

6. Department of Clinical Science and Education, Sodersxjukhuset, Karolinska Institutet, Stockholm, Sweden;

7. Pulmonary and Critical Care Medicine, Department of Medicine,

8. Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts;

9. Sean M. Healey and AMG Center for ALS,

10. Neurological Clinical Research Institute,

11. Anesthesia Research Center,

12. Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; and

13. Critical Care Medicine, Department of Medicine, Louisiana State University Health Shreveport, Shreveport, Louisiana

14. Division of Pediatric Critical Care Medicine, Department of Pediatrics,

15. Anesthesia Critical Care Center for Research, and

16. Department of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden;

17. Respiratory Care Services, Massachusetts General Hospital, Boston, Massachusetts;

Funder

Massachusetts General Hospital

Mallinckrodt Pharmaceuticals

Foundation for the NIH

University of Alabama at Birmingham

Beth Israel Deaconess Medical Center

Louisiana State University Shreveport

Danderyd Hospital

Linde plc

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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