An All-Oral 6-Month Regimen for Multidrug-Resistant Tuberculosis: A Multicenter, Randomized Controlled Clinical Trial (the NExT Study)

Author:

Esmail Aliasgar12ORCID,Oelofse Suzette12,Lombard Carl34,Perumal Rubeshan12,Mbuthini Linda1,Goolam Mahomed Akhter5,Variava Ebrahim678,Black John9,Oluboyo Patrick10,Gwentshu Nelile11,Ngam Eric11,Ackerman Tertius12,Marais Linde12,Mottay Lynelle12,Meier Stuart12,Pooran Anil12,Tomasicchio Michele12,Te Riele Julian13,Derendinger Brigitta14,Ndjeka Norbert15,Maartens Gary16,Warren Robin14,Martinson Neil1718,Dheda Keertan1219ORCID

Affiliation:

1. Division of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa;

2. Centre for the Study of Antimicrobial Resistance, South African Medical Research Council, and

3. Biostatistics Unit, South African Medical Research Council, Cape Town, South Africa;

4. Division of Epidemiology and Biostatistics, Department of Global Health, University of Stellenbosch, Cape Town, South Africa;

5. Department of Intensive Care, Medunsa Campus, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa;

6. Department of Internal Medicine, and

7. Department of Health, North West Province, Mahikeng, South Africa;

8. Perinatal HIV Research Unit, Soweto, South Africa;

9. Department of Internal Medicine, Livingstone Tertiary Hospital, Walter Sisulu University, Gqeberha, South Africa;

10. Department of Medicine, Head of Pulmonology, Nelson Mandela Academic Hospital, Walter Sisulu University, Mthatha, South Africa;

11. Don Makenzie Hospital, Durban, South Africa;

12. Harry Comay Hospital, George, South Africa;

13. Brooklyn Chest Hospital, Cape Town, South Africa;

14. Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa;

15. Drug Resistant Tuberculosis Directorate, National Department of Health, Pretoria, South Africa;

16. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa;

17. Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa;

18. Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland; and

19. Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

Funder

South African Medical Research Council

European and Developing Countries Clinical Trials Partnership

Wellcome Trust

Medical Research Council

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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