Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk

Author:

Abdel-Aziz Mahmoud I.1234ORCID,Thorsen Jonathan56,Hashimoto Simone1723,Vijverberg Susanne J. H.123,Neerincx Anne H.123,Brinkman Paul123,van Aalderen Wim7,Stokholm Jakob58,Rasmussen Morten Arendt58,Roggenbuck-Wedemeyer Michael910,Vissing Nadja H.5,Mortensen Martin Steen9,Brejnrod Asker Daniel11,Fleming Louise J.1213,Murray Clare S.1415,Fowler Stephen J.1415,Frey Urs16,Bush Andrew1213,Singer Florian1718,Hedlin Gunilla1920,Nordlund Björn1920,Shaw Dominick E.21,Chung Kian Fan1213,Adcock Ian M.1213ORCID,Djukanovic Ratko22,Auffray Charles23,Bansal Aruna T.24,Sousa Ana R.25,Wagers Scott S.26,Chawes Bo Lund6,Bønnelykke Klaus6,Sørensen Søren Johannes9,Kraneveld Aletta D.27,Sterk Peter J.12,Roberts Graham22ORCID,Bisgaard Hans5,Maitland-van der Zee Anke H.1723,Kolmert Johan,James Anna,Sousa Ana R.,Riley John H.,Bates Stewart,Bakke Per S.,Caruso Massimo,Chanez Pascal,Fowler Stephen J.,Geiser Thomas,Howarth Peter,Horvath Ildiko,Krug Norbert,Montuschi Paolo,Sanak Marek,Behndig Annelie,Shaw Dominick E.,Knowles Richard G.,Holweg Cecile T. J.,Wheelock Asa M.,Dahlen Barbro,Alving Kjell,Fan Chung Kian,Adcock Ian M.,Sterk Peter J.,Djukanovic Ratko,Dahlen Sven-Erik,Wheelock Craig E.,Andersson Lars,Auffray Charles,Bisgaard Hans,De Meulder Bertrand,Fleming Louise J.,Frey Urs,Lutter Rene,Mumby Sharon,Roberts Graham,Uddin M.,Wagers S. S.,Zounemat Kermani N.

Affiliation:

1. Department of Pulmonary Medicine and

2. Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands;

3. Amsterdam Public Health, Amsterdam, the Netherlands;

4. Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt;

5. Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital,

6. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, and

7. Department of Paediatric Pulmonary Medicine, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands;

8. Department of Food Science, University of Copenhagen, Frederiksberg, Denmark;

9. Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark;

10. Novozymes, Bagsvaerd, Denmark;

11. Section of Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark;

12. National Heart and Lung Institute, Imperial College London, London, United Kingdom;

13. Royal Brompton and Harefield NHS Trust, London, United Kingdom;

14. Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom;

15. Manchester Academic Health Science Centre and National Institute for Health and Care Research Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom;

16. University Children’s Hospital Basel, University of Basel, Basel, Switzerland;

17. Division of Paediatric Pulmonology and Allergology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria;

18. Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;

19. Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden;

20. Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden;

21. National Institute for Health and Care Research Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom;

22. National Institute for Health and Care Research Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and Clinical and Experimental Sciences and Human Development and Health, University of Southampton, Southampton, United Kingdom;

23. European Institute for Systems Biology and Medicine, CIRI UMR5308, CNRS-ENS-UCBL-INSERM, Lyon, France;

24. Acclarogen Ltd., St. John’s Innovation Centre, Cambridge, United Kingdom;

25. Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, United Kingdom;

26. BioSci Consulting, Maasmechelen, Belgium; and

27. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands

Funder

Innovative Medicines Initiative

FP7 Health

Ministry of Higher Education

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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