A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities

Author:

Moll Matthew12,Peljto Anna L.34ORCID,Kim John S.5,Xu Hanfei6,Debban Catherine L.7,Chen Xianfeng8,Menon Aravind1ORCID,Putman Rachel K.1,Ghosh Auyon J.9,Saferali Aabida2,Nishino Mizuki10,Hatabu Hiroto10,Hobbs Brian D.12,Hecker Julian2,McDermott Gregory11,Sparks Jeffrey A.11,Wain Louise V.1213,Allen Richard J.1213,Tobin Martin D.1213,Raby Benjamin A.21415,Chun Sung15,Silverman Edwin K.12,Zamora Ana C.8,Ortega Victor E.8,Garcia Christine K.16ORCID,Barr R. Graham317,Bleecker Eugene R.18,Meyers Deborah A.18,Kaner Robert J.19,Rich Stephen S.7,Manichaikul Ani7,Rotter Jerome I.20,Dupuis Josée621,O’Connor George T.22,Fingerlin Tasha E.23,Hunninghake Gary M.1,Schwartz David A.34,Cho Michael H.12

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, and

2. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts,

3. Department of Medicine and

4. Department of Immunology, Division of Pulmonary Medicine, University of Colorado, Aurora, Colorado;

5. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, Virginia;

6. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts;

7. Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia;

8. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Phoenix, Arizona;

9. Department of Medicine, Division of Pulmonary and Critical Care Medicine, State University of New York Upstate Medical Center, Syracuse, New York;

10. Center for Pulmonary Functional Imaging, Department of Radiology,

11. Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts;

12. Department of Health Sciences, University of Leicester, Leicester, United Kingdom;

13. National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom;

14. Department of Pediatrics,

15. Division of Pulmonary Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;

16. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York;

17. Division of General Medicine, Department of Epidemiology, Columbia University Medical Center, New York, New York;

18. Division of Genetics, Genomics, and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Arizona;

19. Division of Pulmonary Medicine, Weill Cornell School of Medicine, New York, New York;

20. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles Medical Center, Torrance, California;

21. Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University Faculty of Medicine and Health Sciences, Montreal, Quebec, Canada;

22. Department of Medicine, Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts; and

23. The National Jewish Health Cohen Family Asthma Institute, Division of Allergy and Immunology, National Jewish Health, Denver, Colorado

Funder

National Heart, Lung, and Blood Institute

Alpha-1 Foundation

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Cancer Institute

U.S. Department of Veterans Affairs

U.S. Department of Defense

GlaxoSmithKline

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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