Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Author:

Illi Sabina12ORCID,Depner Martin3,Pfefferle Petra Ina45,Renz Harald675,Roduit Caroline8910,Taft Diana Hazard11,Kalanetra Karen M.11,Mills David A.11,Farquharson Freda M.12,Louis Petra12,Schmausser-Hechfellner Elisabeth13,Divaret-Chauveau Amandine141516,Lauener Roger179,Karvonen Anne M18,Pekkanen Juha1918,Kirjavainen Pirkka V.2021,Roponen Marjut22,Riedler Josef23,Kabesch Michael24,Schaub Bianca255,von Mutius Erika1265,

Affiliation:

1. Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Gesundheit und Umwelt, 9150, Institute of Asthma and Allergy Prevention, Neuherberg, Germany

2. German Center for Lung Research, 542891, Giessen, Germany;

3. Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Umwelt und Gesundheit, 9150, Institute of Asthma and Allergy Prevention, Neuherberg, Germany

4. Philipps-Universität Marburg Fachbereich Medizin, 98594, Comprehensive Biobank Marburg CBBM, Marburg, Germany

5. German Center for Lung Research, 542891, Giessen, Germany

6. Philipps-Universität Marburg, 9377, Institute of Laboratory Medicine, Marburg, Germany

7. Sechenov University, 68477, Department of Clinical Immunology and Allergology, Laboratory of Immunopathology, Moskva, Russian Federation

8. University of Zurich, Children's Hospital, Zurich, Switzerland

9. Christine Kühne Center for Allergy Research and Education (CK-CARE) , Davos, Switzerland

10. Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland

11. University of California Davis, 8789, Department of Food Science & Technology, Davis, California, United States

12. University of Aberdeen, 1019, The Rowett Institute, Aberdeen, United Kingdom of Great Britain and Northern Ireland

13. Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, 9150, Institute of Asthma and Allergy Prevention, Neuherberg, Germany

14. Burgundy Franche-Comté University, 439716, UMR 6249 Chrono-environment , Besancon, France

15. University of Lorraine, 137665, EA3450 Développement Adaptation et Handicap (DevAH) , Nancy, France

16. University Hospital Centre Nancy, 26920, Pediatric Allergy Department, Nancy, France

17. Children’s Hospital of Eastern Switzerland, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland

18. Finnish Institute for Health and Welfare, 3837, Department of Health Security, Helsinki, Finland

19. University of Helsinki, Department of Public Health, Helsinki, Finland

20. Finnish Institute for Health and Welfare, 3837, Department of Health Security, Kuopio, Finland

21. University of Eastern Finland, 163043, Institute of Public Health and Clinical Nutrition, Kuopio, Finland

22. University of Eastern Finland, 163043, Department of Environmental and Biological Sciences, Kuopio, Finland

23. Children's Hospital Schwarzach, Children's Hospital Schwarzach, Schwarzach, Austria

24. University Children’s Hospital Regensburg (KUNO), Department of Pediatric Pneumology and Allergy, Campus St. Hedwig, Regensburg, Germany

25. Ludwig-Maximilians-Universitat Munchen, 9183, Dr. von Hauner Children's Hospital, Munchen, Germany

26. Ludwig-Maximilians-Universitat Munchen, 9183, Dr. von Hauner Children's Hospital, München, Germany

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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