SARS-CoV-2 Viral Replication Persists in the Human Lung for Several Weeks after Symptom Onset

Author:

Tomasicchio Michele12ORCID,Jaumdally Shameem12,Wilson Lindsay12,Kotze Andrea12,Semple Lynn12,Meier Stuart12,Pooran Anil12,Esmail Aliasgar12,Pillay Komala3,Roberts Riyaadh3,Kriel Raymond3,Meldau Richard12,Oelofse Suzette12,Mandviwala Carley12,Burns Jessica12,Londt Rolanda12,Davids Malika12,van der Merwe Charnay12,Roomaney Aqeedah12,Kühn Louié12,Perumal Tahlia12,Scott Alex J.12,Hale Martin J.4,Baillie Vicky56,Mahtab Sana56,Williamson Carolyn7,Joseph Rageema7,Sigal Alex8,Joubert Ivan9,Piercy Jenna9,Thomson David9,Fredericks David L.9,Miller Malcolm G. A.9,Nunes Marta C.5610,Madhi Shabir A.56,Dheda Keertan121112ORCID

Affiliation:

1. Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, University of Cape Town and UCT Lung Institute, Cape Town, South Africa;

2. South African MRC Centre for the Study of Antimicrobial Resistance,

3. Division of Anatomical Pathology, Department of Pathology, and

4. Division of Anatomical Pathology,

5. South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, and

6. Department of Science and Technology/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa;

7. Division of Medical Virology,

8. Africa Health Research Institute, Durban, South Africa; and

9. Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa;

10. Centre of Excellence in Respiratory Pathogens, Hospices Civils de Lyon and Centre International de Recherche en Infectiologie, Équipe Santé Publique, Épidémiologie et Écologie Évolutive des Maladies Infectieuses, Inserm U1111, CNRS UMR5308, ENS de Lyon, Université Claude Bernard – Lyon 1, Lyon, France

11. Institute of Infectious Disease and Molecular Medicine,

12. Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, United Kingdom;

Funder

Division of Research Capacity Development

Publisher

American Thoracic Society

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