Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease

Author:

Madapoosi Siddharth S.1,Cruickshank-Quinn Charmion2,Opron Kristopher1,Erb-Downward John R.1,Begley Lesa A.1,Li Gen3,Barjaktarevic Igor4,Barr R. Graham56,Comellas Alejandro P.7ORCID,Couper David J.8,Cooper Christopher B.4,Freeman Christine M.1,Han MeiLan K.1,Kaner Robert J.9,Labaki Wassim1,Martinez Fernando J.9,Ortega Victor E.10,Peters Stephen P.10,Paine Robert11,Woodruff Prescott12,Curtis Jeffrey L.113ORCID,Huffnagle Gary B.114,Stringer Kathleen A.15ORCID,Bowler Russell P.1617,Esther Charles R.1819,Reisdorph Nichole2,Huang Yvonne J.120ORCID,Alexis Neil E.,Anderson Wayne H.,Arjomandi Mehrdad,Bateman Lori A.,Bhatt Surya P.,Bleecker Eugene R.,Boucher Richard C.,Christenson Stephanie A.,Criner Gerard J.,Crystal Ronald G.,Doerschuk Claire M.,Dransfield Mark T.,Drummond Brad,Galban Craig,Hansel Nadia N.,Hastie Annette T.,Hoffman Eric A.,Kanner Richard E.,Kleerup Eric C.,Krishnan Jerry A.,LaVange Lisa M.,Lazarus Stephen C.,Meyers Deborah A.,Moore Wendy C.,Newell John D.,Paulin Laura,Pirozzi Cheryl,Putcha Nirupama,Oelsner Elizabeth C.,O’Neal Wanda K.,Raman Sanjeev,Rennard Stephen I.,Tashkin Donald P.,Wells J. Michael,Wise Robert A.

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, Department of Medicine,

2. Department of Pharmaceutical Sciences, University of Colorado, Anschutz Campus, Aurora, Colorado;

3. Department of Biostatistics, School of Public Health,

4. University of California at Los Angeles, Los Angeles, California;

5. Department of Medicine and

6. Department of Epidemiology, Columbia University Medical Center, New York, New York;

7. University of Iowa, Iowa City, Iowa;

8. Department of Biostatistics,

9. Weill Cornell Medical College, New York, New York;

10. Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina;

11. University of Utah, Salt Lake City, Utah;

12. University of California at San Francisco, San Francisco, California;

13. Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan;

14. Department of Molecular, Cellular and Developmental Biology,

15. Department of Clinical Pharmacy, College of Pharmacy, and

16. School of Medicine, University of Colorado, Aurora, Colorado; and

17. Department of Medicine, National Jewish Health, Denver, Colorado

18. Division of Pediatric Pulmonology, and

19. Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

20. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan;

Funder

National Institute of Allergy and Infectious Diseases

National Heart, Lung, and Blood Institute

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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