Pharmacological Improvement of Cystic Fibrosis Transmembrane Conductance Regulator Function Rescues Airway Epithelial Homeostasis and Host Defense in Children with Cystic Fibrosis

Author:

Loske Jennifer12ORCID,Völler Mirjam3,Lukassen Sören4,Stahl Mirjam356ORCID,Thürmann Loreen1,Seegebarth Anke1,Röhmel Jobst356,Wisniewski Sebastian3,Messingschlager Marey12,Lorenz Stephan7,Klages Sven7,Eils Roland8469,Lehmann Irina16ORCID,Mall Marcus A.356ORCID,Graeber Simon Y.356ORCID,Trump Saskia1ORCID

Affiliation:

1. Center of Digital Health, Molecular Epidemiology Unit, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany;

2. Department of Biology and

3. Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany;

4. Center of Digital Health, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany;

5. Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany;

6. German Center for Lung Research, Associated Partner Site, Berlin, Germany;

7. Max Planck Institute for Molecular Genetics, Berlin, Germany;

8. Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany;

9. Health Data Science Unit, BioQuant, Medical Faculty, University of Heidelberg, Heidelberg, Germany

Funder

Mukoviszidose Institut gGmbH

German Federal Ministry of Education and Research

German Research Foundation

Publisher

American Thoracic Society

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