Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis Trial

Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis Trial—MIST-3

Published:2023-12-15 Issue:12 Volume:208 Page:1305-1315
ISSN:1073-449X
Container-title:American Journal of Respiratory and Critical Care Medicine
language:en
Short-container-title:Am J Respir Crit Care Med

Author:

Bedawi Eihab O.¹²³⁴⁵^ORCID,Stavroulias Dionisios⁶,Hedley Emma¹,Blyth Kevin G.⁷⁸,Kirk Alan⁹,De Fonseka Duneesha⁵,Edwards John G.¹⁰,Internullo Eveline¹¹,Corcoran John P.¹²,Marchbank Adrian¹³,Panchal Rakesh¹⁴,Caruana Edward¹⁵,Kadwani Owais¹²,Okiror Lawrence¹⁶,Saba Tarek¹²,Purohit Manoj¹⁷,Mercer Rachel M.¹⁸,Taberham Rhona⁶,Kanellakis Nikolaos¹²¹⁹²⁰,Condliffe Alison M.⁴⁵,Lewis Leon G.⁵,Addala Dinesh N.¹²³,Asciak Rachelle¹⁸,Banka Radhika²¹,George Vineeth²²²³,Hassan Maged²⁴^ORCID,McCracken David²⁵,Sundaralingam Anand¹³,Wrightson John M.¹³,Dobson Melissa¹²,West Alex¹²,Barnes Graham²⁶,Harvey John²⁷²⁸,Slade Mark²⁹,Chester-Jones Mae³⁰,Dutton Susan³⁰,Miller Robert F.³¹,Maskell Nick A.²⁷²⁸,Belcher Elizabeth⁶,Rahman Najib M.¹²¹⁹²⁰³

Affiliation:

1. Oxford Respiratory Trials Unit, Nuffield Department of Medicine,

2. National Institute for Health and Care Research Oxford Biomedical Research Centre,

3. Oxford Centre for Respiratory Medicine and

4. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom;

5. Academic Directorate of Respiratory Medicine,

6. Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals National Health Service (NHS) Foundation Trust, Oxford, United Kingdom;

7. School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom;

8. Department of Respiratory Medicine, Queen Elizabeth University Hospital, Glasgow, United Kingdom;

9. Department of Thoracic Surgery, Golden Jubilee National Hospital, Glasgow, United Kingdom;

10. Department of Thoracic Surgery, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom;

11. Department of Thoracic Surgery, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom;

12. Department of Respiratory Medicine and

13. Department of Cardiothoracic Surgery, Derriford Hospital, University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom;

14. Department of Respiratory Medicine, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom;

15. Department of Thoracic Surgery, Glenfield Hospitals, University Hospitals of Leicester, Leicester, United Kingdom;

16. Department of Thoracic Surgery, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom;

17. Department of Cardiothoracic Surgery, Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, United Kingdom;

18. Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom;

19. Laboratory of Pleural and Lung Cancer Translational Research,

20. Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, and

21. Department of Respiratory Medicine, PD Hinduja National Hospital, Mumbai, India;

22. Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia;

23. Hunter Medical Research Institute, Newcastle, New South Wales, Australia;

24. Chest Diseases Department, Alexandria University, Alexandria, Egypt;

25. Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland;

26. Patient representative, Oxford, United Kingdom;

27. Department of Respiratory Medicine, North Bristol NHS Trust, Bristol, United Kingdom;

28. Academic Respiratory Unit, University of Bristol, Bristol, United Kingdom;

29. Department of Respiratory Medicine, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, United Kingdom; and

30. Oxford Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom;

31. Institute for Global Health, University College London, London, United Kingdom

Funder

Research for Patient Benefit Programme

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Link

https://www.atsjournals.org/doi/pdf/10.1164/rccm.202305-0854OC

Reference36 articles.

1. Precision-guided, Personalized Intrapleural Fibrinolytic Therapy for Empyema and Complicated Parapneumonic Pleural Effusions: The Case for The Fibrinolytic Potential

2. Epidemiology of Adult Pleural Disease in the United States

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5. A systematic review of comorbidities and outcomes of adult patients with pleural infection

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